The 30-second spot contrasts Edwards' service as an Army Ranger with Vitter's connection to the so-called "D.C. Madam" scandal. The ad's narrator claims Vitter took a call from a prostitute "minutes after he skipped a vote honoring 28 soldiers who gave their lives in defense of our freedom."
"David Vitter chose prostitutes over patriots," the ad's narrator says. "Now, the choice is yours."
Vitter admitted to committing a "very serious sin" after his phone number appeared on the client list of the "D.C. Madam" in 2007.
The ad will begin running statewide Saturday during the Louisiana State University-Alabama football game, according to the Edwards campaign.
"The buy for this ad will be significant enough to ensure that voters have the facts about David Vitter," spokeswoman Mary-Patricia Wray said in an email to TPM.