Asked during an interview with CNN's Jake Tapper about Trump's "crooked Hillary" nickname, Clinton said types of comments from men were common in her experience.
"I have a lot of experience dealing with men who sometimes get 'off the reservation' in the way they behave and how they speak," Clinton said. "I'm not going to deal with their temper tantrums or efforts to try to provoke me."
The former secretary of state didn't specify who else she was referring to.
Trump and Clinton both have shifted their rhetoric toward the general election fight in recent days. When Tapper asked about Trump's now infamous "woman card" attacks on her, she chalked them up to "bullying."
"He can say whatever he wants to say about me, I could really care less," Clinton said. "I'm going to stand up for what I think the American people need and want in the next president."
Clinton also referenced a report that Trump's camp planned to go after supporters of Sen. Bernie Sanders (I-VT) who it didn't think would vote for Clinton in a general election, saying she doesn't see how that could work.
"I don't see how the calculation adds up," Clinton said. "If you don't believe in raising minimum wage, you don't think the wages are enough in America. If you demean women, you don't believe equal pay is important. If you have a kind of reckless, loose, dangerous view of foreign policy, I don't think that's very appealing."