The cover story, which is available to subscribers now and will hit newsstands next week, was written by Buzz Bissinger, who followed Jenner after her transition surgery and interviewed a number of her family members.
In the ABC interview, Jenner, then still going by male identifiers and the name Bruce, announced he was a woman. It was watched by 16.9 million viewers and was hailed as a watershed moment for transgender rights. A reality docu-series starring Jenner will premiere on E! next month.
The Jenner's Vanity Fair comes just in time for LGBT pride month. She also launched her new Twitter account with the release of the cover image.
I'm so happy after such a long struggle to be living my true self. Welcome to the world Caitlyn. Can't wait for you to get to know her/me.
— Caitlyn Jenner (@Caitlyn_Jenner) June 1, 2015